TB-500 2mg (Euro-Pharmacies, Europe)

TB-500 is a synthetic counterpart of the naturally occurring peptide found in nearly all human and animal cells, known as Thymosin Beta 4 (TB-500). It is a pioneering drug candidate that facilitates:

   Differentiation of endothelial (blood vessel) cells
   Angiogenesis (the formation of new blood vessels from existing ones) in dermal tissues
   Migration of keratinocytes
   Collagen deposition; and
   Reduction of inflammation.

A primary mechanism of action for TB-500 is its capacity to modulate the cell-structuring protein, Actin, which is essential for cellular structure and movement. Among the myriad of proteins in cells, actin constitutes up to 10% of the total protein content, significantly influencing the cell's genetic composition.

This powerful peptide belongs to a widespread family of 16 related molecules distinguished by a high level of sequence conservation and presence in various tissues and circulating cells throughout the body. TB-500 not only interacts with actin but also inhibits actin polymerization, acting as the actin-sequestering molecule within eukaryotic cells.

TB-500 was recognized as a gene that is up-regulated four to six times during the initial stages of blood vessel development and has been found to stimulate the formation of new blood vessels from pre-existing ones. This peptide is present in wound exudate and, when administered subcutaneously, enhances wound healing, promotes muscle growth, and accelerates recovery times for muscle fibers and their cells.

Another significant aspect of TB-500 is its ability to encourage cell migration through a specific interaction with actin in the cytoskeleton. Research has shown that a central small amino acid long-actin binding domain possesses both blood cell reproduction and wound healing properties. These effects are realized by enhancing the movement of endothelial cells and keratinocytes, as well as increasing the production of enzymes that degrade the extracellular matrix.

Studies confirm that TB-500 is a powerful, naturally occurring factor for wound repair with anti-inflammatory effects. Unlike other repair factors, such as growth factors, TB-500 promotes migration of endothelial and keratinocyte cells. It also does not attach to the extracellular matrix and has a low molecular weight, allowing it to travel relatively long distances within tissues.